INL researchers are exploring new ways to predict breast cancer metastasis

January 21, 2025

A research project called 3DSecret is exploring innovative methods to predict breast cancer metastasis by analysing tumour cells circulating in the bloodstream. 3DSecret focuses on understanding how these cells contribute to cancer spreading to distant organs, which is the primary cause of mortality in breast cancer patients.

Breast cancer metastasis often occurs via the hematogenous route, i.e. through the bloodstream. The presence of circulating tumour cells (CTCs) provides an opportunity to study the disease through blood samples rather than invasive tissue biopsies.

Using specialised devices, INL researchers can isolate these tumour cells from blood samples. The next step involves cultivating individual CTCs in an artificial culture system, in the lab, designed to mimic their natural environment.

Data from these cultures are then analysed using artificial intelligence algorithms. By examining the genetic profiles of the tumour cells and the substances they secrete, the project aims to identify unknown drivers of breast cancer metastasis.

Recently, the project technical coordinator, Miguel Xavier, was at ‘90 Segundos de Ciência’, a series of science communication episodes with daily broadcasts on the Portuguese public radio Antena 1. Miguel is confident about the broader implications of this project, “this research could provide insights into the relationship between specific tumour characteristics and their metastatic potential, aiming to contribute toward improving existing cancer therapies”. The 3DSecret project is funded by the Horizon Europe program and UKRI, and represents a collaborative effort between partners from Portugal, Spain, Italy, and the UK, to improve breast cancer prognosis through advanced technology.

Text and Photography by Catarina Moura, Science Communication Officer