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Advanced electron microscopy to investigate magnetic layered materials

In a recent study published in Nature Communications, INL researchers Loukya Boddapati and Francis Leonard Deepak, along with an international team from Korea, Spain, the U.S., and the U.K., used cutting-edge electron microscopy, including low-temperature Cryo-TEM, to explore the structural phase transitions of CrI₃. CrI₃ is a novel magnetic material which has attracted significant attention for its unique ferromagnetic properties and potential applications in spintronics. The stacking configurations in van der Waals crystals significantly influence several material properties. Previous research has shown that stacking engineering is a powerful method for achieving desired properties through layer-by-layer crystal engineering. Controlling the twist angle between artificially stacked two-dimensional (2D) materials has led to the discovery of unconventional phenomena, ranging from superconductivity to strongly correlated magnetism. This study clarifies the complex relationship between these transitions and the material’s magnetic properties. In this study, cross-sectional TEM analysis was used to identify interlayer stacking disorders in CrI3. According to Francis Leonard Deepak, “the study provides evidence of twisted stacking faults in CrI₃ and reveals changes in the relative population of twisted domains, without the anticipated transition to the rhombohedral phase at low temperatures”. “These findings underscore the importance of understanding layer-dependent stacking order and magnetic properties […]

INL welcomes the new Deputy Director-General

Professor Doctor Ado Jório de Vasconcelos appointed to be the new Deputy Director-General of INL The Council of the International Iberian Nanotechnology Laboratory (INL) has announced the appointment of Prof. Dr. Ado Jório de Vasconcelos as Deputy Director-General of INL, effective from the 2nd of September 2024. He will join the Director-General of INL, Prof. Dr. Clivia M. Sotomayor Torres, to provide strategic direction and leadership. Together, they will bring INL into a new phase that is fit for the challenges faced by research organisations in a rapidly changing world that requires bespoke science excellence and innovation as expressions of social engagement. As Deputy Director-General, Prof. Dr. Jório de Vasconcelos will be responsible for driving innovation, fostering the institute’s mission of advancing nanotechnology research and innovation and promoting the organisation’s global impact on society. Professor Dr. Ado Jório de Vasconcelos has a distinguished career as internationally acclaimed researcher, university teacher and administrator, innovator, and policy maker. He brings a particular international dimension based on his career path in the Americas. The INL community looks forward to his arrival and to working with him. INL Directorate Office

Researchers achieve quantum breakthrough with novel quantum-to-quantum Bernoulli factory design

Unlike classical computers, which use bits to process information as either 0s or 1s, quantum computers use quantum bits, also known as qubits, which can represent and process both 0 and 1 simultaneously thanks to a quantum property called superposition. This fundamental difference gives quantum computers the potential to solve some complex problems much more efficiently than classical computers. INL researcher Ernesto Galvão, in collaboration with Sapienza Università di Roma (Rome) and Istituto di Fotonica e Nanotecnologie (Milan), recently published a groundbreaking study in the journal Science Advances, where they describe a new set-up for a quantum-to-quantum Bernoulli factory. A Bernoulli factory is a method to manipulate randomness, using as inputs random coin flips with a certain probability distribution, and outputting coin flips with a different, desired distribution. Let us imagine we have a coin that lands on heads with some unknown probability. Now, we want to create a new coin that lands on heads with a different probability, possibly described by a function of the initial probability. The Bernoulli factory is an ingenious way to flip our original coin multiple times and use the different outcomes to simulate the new coin with the desired probability. Ernesto Galvão adds “This […]

Filipa Lebre: Exploring the Frontier of Nanosafety

Filipa Lebre is a Research Fellow in the Nanosafety Research Group at INL, and her research focuses on the complex interactions among the immunological system and different organs, using novel technologies and in-house developed systems. Filipa has a background in Pharmaceutical Sciences and holds a PhD in Pharmaceutical Technology from the Faculty of Pharmacy, University of Coimbra, focused on the development and optimization of a polymeric nasal vaccine against hepatitis B to be used for mass immunization. She moved to Ireland during her postdoc to conduct her research at the interface between biomaterial and immunology, studying key aspects of immunomodulation by a relevant spectrum of materials with applicability in the regenerative medicine field. Could you share with us your professional trajectory and what inspired you to embark on a career in nanosafety? I’m very curious by nature and always had this passion and interest in science. When I did my degree in Pharmaceutical Science, I was fortunate enough to find a teacher who was working in the vaccine field and made me realize how I could use my passion to impact millions of lives. That was when I started to work with nanoformulations. I obtained my PhD in formulation development, […]

Can we cut the energy consumption of current AI technologies?

As artificial intelligence, commonly referred to as AI, becomes increasingly integrated into various aspects of our daily lives, the energy demands of AI systems continue to rise. Despite AI being inspired by the human brain, it is significantly less energy efficient because most tasks are implemented on computer hardware that is not specifically tailored for this purpose. The human brain remains an exemplar of energy-efficient computation, a standard that modern technology strives to replicate. INL researchers are studying advanced materials and devices aimed at revolutionising AI systems. Carlos Rosário, ERA fellow at INL (Marie Skłodowska-Curie actions (MSCA)), focuses his research on reducing the substantial energy consumption required by current AI technologies. Carlos’ work is grounded in the field of neuromorphic computing, which seeks to mimic the brain’s intricate network of neurons and synapses using artificial equivalents. The goal is to create an electronic brain capable of performing complex computations with minimal energy use. One of the key areas of Carlos Rosário’s research is the exploration of 3D topological insulators for novel electronic devices. These cutting-edge materials exhibit unique properties: while they are insulators and do not conduct electricity through their bulk, their surfaces behave like metals, allowing for efficient electrical […]

Secretary of State for Science Visits INL, Showcasing Key Projects and Innovations

Prof. Dr Ana Paiva, Secretary of State for Science, visited INL – International Iberian Nanotechnology Laboratory today. This visit provided an exceptional platform for INL to present its ongoing projects and significant achievements in the field of science and technology. The presence of Prof. Dr. Paiva underscored the crucial role of INL’s work and its far-reaching impact on the broader scientific community. Prof. Dr. Clivia M. Sotomayor Torres, INL Director-General, welcomed Prof. Dr Paiva and provided an insightful overview of INL’s mission and accomplishments. This introduction set the stage for a series of detailed presentations and discussions that highlighted INL’s prominence in both the national and European research landscapes. Presentation Highlights: Secretary of State’s visit to INL was a testament to the laboratory’s dedication to innovation, excellence, and its significant contributions to the field of science and technology. This visit not only highlighted INL’s achievements but also reinforced the importance of continued support and investment in scientific research and development. Text and Photography by Gina Palha

Breakthrough technology for cancer diagnostics

INL researchers are part of the consortium behind BIOCELLPHE, a pioneering project focused on advancing cancer diagnostics and personalised medicine. This innovative European-funded project is at the forefront of scientific and technological innovation, introducing a groundbreaking technology for identifying proteins as diagnostic biomarkers at the single-cell level. This new approach offers multiplexing capabilities, portability and enhanced sensitivity. Alexandra Teixeira, research fellow at the Medical Devices group, highlights that “BIOCELLPHE is pioneering the use of engineered bacteria to recognise and bind with high specificity to protein targets on the surface of circulating tumour cells, or CTCs, which are key players in cancer metastasis.” This specific binding of engineered bacteria to CTCs subsequently triggers the production of molecules (Raman reporters), which can be detectable with high sensitivity using surface-enhanced Raman scattering (SERS). More specifically, SERS uses plasmonic nanoparticles to enhance Raman signals, allowing ultrasensitive analysis and detection at the single molecule level. The pathological role of CTCs in cancer metastasis is not completely understood due to the lack of effective analytical tools and remains an area that needs further exploration. BIOCELLPHE addresses this gap by developing new tools for the phenotypic identification of CTCs at the single-cell level, with high-throughput and multiplexing […]

INL’s Official Mourning Day in honour of Manuel Cargaleiro

The Portuguese Government declared today, July 2nd, a National Day of Mourning in honour of Manuel Cargaleiro. The mourning coincides with the funeral of Master Manuel Cargaleiro. Cargaleiro was a multifaceted artist renowned for his painting and ceramist work. He mastered colour and geometry remarkably, giving contemporary Portuguese art its unmistakable character. Throughout his career, his creations expressed his poetic vision of the world, building a legacy recognized by several generations of Portuguese people. His work, represented in national collections such as the State Contemporary Art Collection, as well as in international ones, was highly honoured. His accolades include Commander of the Order of Santiago da Espada de Portugal (1983), Officer of the Order of Arts and Letters from the French government (1984), Grand Cross of the Order of Merit (1989), Grand Cross of the Order of Infante D. Henrique (2017), Medal of Cultural Merit (2019), Grand Vermeil Medal (2019), and the Grand Cross of the Order of Camões (2023). Cargaleiro maintained an intense artistic activity throughout his life, creating an essential legacy for 20th-century Portuguese art. His unique style bridged various references and generations. Despite being a global figure, he remained deeply connected to his roots, choosing Castelo Branco […]

A miniaturised model of human digestion to advance therapies and nutritional products

INL researchers have made a significant breakthrough in the development of reliable in-vitro digestion models. This ‘digestion-chip’ promises to revolutionise the way new oral formulations are tested, offering a more accurate, efficient, and cost-effective alternative to current models. Traditional in-vitro digestion models often fail to replicate the complex dynamics of the human gastrointestinal tract. They either lack critical digestive processes or require large volumes of samples and reagents, which can be challenging when dealing with nanomaterials. The INL’s innovative ‘digestion-chip’ addresses these limitations with its miniaturised design and advanced features. The coordinator of the study Catarina Gonçalves explains, “the Food Processing and Nutrition research group proposes a miniaturised digestion system based on incubation chambers integrated into a polymethylmethacrylate device. This solution incorporates key dynamic features of human digestion while maintaining low complexity and using small volumes of samples and reagents”. The digestion-chip features gradual acidification (the stepwise addition of enzymes and simulated fluids during the gastric phase) and controlled gastric emptying. These capabilities are essential for replicating the intricate environment of the human stomach and intestines. The research team’s experimental results indicate that “the ‘digestion-chip’ successfully replicates the established static digestion INFOGEST protocol”. Moreover, “the semi-dynamic digestion kinetics observed with […]

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