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Nanotechnology for predicting and preventing seizures in neurological diseases

Nanotechnology for predicting and preventing seizures in neurological diseases

INL researchers are part of the European consortium CROSSBRAIN – a groundbreaking project aimed at developing microbots to predict and prevent seizures in individuals suffering from conditions such as epilepsy or Alzheimer’s disease. Within the complexity of our brains, neurons communicate through various signalling mechanisms, including chemical, thermal, and electrical changes. Many neurological disorders affecting the brain originate from abnormal electrical activity, leading to conditions such as epileptic seizures. When these abnormalities in electrical activity occur, prompt identification and swift intervention are vital for effective treatment. However, current technologies for monitoring and modulating brain activity with precision are very limited. CROSSBRAIN brings together leading researchers from across Europe to develop a new solution for predicting and preventing seizures in neurological conditions. Coordinated by researchers from Tor Vergata University of Rome, the consortium aims to create micro-sized robots that can be implanted in our brains. By combining cutting-edge computing and nanomaterials, CROSSBRAIN will enable precise modulation of brain tissue using various stimulation methods, including electrical, mechanical, thermal, and optical principles. The microbots, powered wirelessly by a compact central unit, will then be implanted through blood vessels, with the capability to deliver genetic material. Once integrated into the network of neurons, these […]

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Olesia Dudik, focused on the development of an electrochemical sensing platform for alkali metal ion detection

Olesia Dudik, focused on the development of an electrochemical sensing platform for alkali metal ion detection

Welcome to a new interview highlighting the indispensable role of women in science. We aim to showcase the remarkable contributions of women working at INL across various disciplines and career stages. Join us as we celebrate their achievements, share their stories, and inspire future generations of female scientists. Olesia Dudik is currently a Research Fellow in the Water Quality Group at the International Iberian Nanotechnology Laboratory (INL). Her research area focuses on sensor development (optical, electrochemical). She holds a BSc and an MSc in organic chemistry from the Taurida National V.I. Vernadsky University (Ukraine) and obtained a PhD degree in Physics and Chemistry of Surface from the Chuiko Institute of Surface Chemistry of NAS of Ukraine in 2014, studying adsorption-desorption processes and mechanisms and kinetics of chemical transformations of aliphatic and biologically active amines (anaesthetics) on the surface of dispersed oxides. Can you give us an update on what you’re currently working on? When I joined INL two years ago, the transition to working in the area of sensor development (optical, electrochemical) from a tissue engineering and regenerative medicine field was a bit challenging. Nevertheless, I was excited by the opportunity to gain new knowledge, and skills and implement them in discoveries. The acquired knowledge helps me grow further professionally.  Nowadays, my research area focuses on […]

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Beatriz Costa, developing 3D scaffolds integrated with nanodiamond photonics platforms

Beatriz Costa, developing 3D scaffolds integrated with nanodiamond photonics platforms

Welcome to a new interview highlighting the indispensable role of women in science. We aim to showcase the remarkable contributions of women working at INL across various disciplines and career stages. Join us as we celebrate their achievements, share their stories, and inspire future generations of female scientists. Today you can meet Beatriz Costa, Junior Research Fellow in the Ultrafast Bio- and Nanophotonics group at INL under the supervision of Dr. Jana B. Nieder. Why did you decide to work in the Ultrafast Bio- and Nanophotonics area? My decision to pursue research in the Ultrafast Bio- and Nanophotonics area stems from its interdisciplinary nature and potential applications in biomedical engineering. With a background in Biomedical Engineering and a Major in Medical Electronics, I sought a field that would enable me to integrate diverse disciplines and cutting-edge technologies to address pressing healthcare challenges. The Ultrafast Bio- and Nanophotonics area offers a unique convergence of optics, nanotechnology, and biology, providing opportunities to develop novel diagnostic and therapeutic approaches. Can you tell us what you are working on at present? Currently, I am engaged in a research project focused on developing 3D scaffolds integrated with nanodiamond photonics platforms. These scaffolds serve as intricate […]

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Detecting food allergens with paper microfluidics and a smartphone

Detecting food allergens with paper microfluidics and a smartphone

Every day, millions are at risk of falling ill due to undetected allergens or contaminants in their food. However, a groundbreaking solution may be on the horizon, as researchers investigate a game-changing technology to combat foodborne risks. The Food Quality and Safety research group recently published a study describing a cutting-edge technology that provides faster, cheaper, and more reliable detection of allergens like β-lactoglobulin in our food. Traditionally, detecting allergens in food products has been a complex and costly process. Current methods, including enzyme-linked immunosorbent assays (ELISA) and polymerase chain reaction (PCR), require specialised equipment and highly-trained personnel, making them difficult to use. INL researchers are contributing to reshaping the landscape of food safety with a new nanotechnology approach. Their pioneering approach? Fluorescent carbon quantum dots combined with aptamers, which are short, single-stranded DNA or RNA molecules that can bind to specific target molecules with high affinity and specificity. By leveraging the unique properties of carbon quantum dots and aptamers, the researchers have developed a highly sensitive and portable detection method for β-lactoglobulin, the primary allergenic whey protein found in cow’s milk. What sets this technology apart is its simplicity and effectiveness. The team has created a user-friendly platform that […]

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Alexandra Teixeira, developing diagnostic tools tailored for accurate MRD diagnosis

Alexandra Teixeira, developing diagnostic tools tailored for accurate MRD diagnosis

Welcome to a new series of interviews highlighting the indispensable role of women in science. Throughout this series, we aim to showcase the remarkable contributions of women scientists across various disciplines and career stages. From groundbreaking research to innovative discoveries, these interviews will provide insight into the diverse and impactful work of women in the scientific community. Join us as we celebrate their achievements, share their stories, and inspire future generations of female scientists. Meet Alexandra Teixeira, PhD Student at INL – International Iberian Nanotechnology Laboratory. Recently defended her PhD thesis entitled: “Development of microfluidic nano biosensors for early diagnosis of acute myeloid leukaemia and monitoring of minimal residual disease” with the highest grade. Could you provide some insights into your background, your primary field of expertise, and the significance of your work? My educational journey started with a degree in Biology and Geology at the University of Minho. However, driven by a passion for health-related sciences, I did a master’s degree and later a PhD in Health Sciences at the School of Medicine, also at the University of Minho. Throughout my career, particularly during PhD, I gained expertise in microfluidics, surface-enhanced Raman scattering spectroscopy (SERS), and next-generation sequencing (NGS). […]

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Is there a nano-sized ‘magic bullet’ for treating cancer?

Is there a nano-sized ‘magic bullet’ for treating cancer?

The Royal Society of Chemistry (RSC) selected a research study from INL as one of the groundbreaking cancer research papers of 2023. This collection of papers aims to highlight recent developments in efforts to understand cancer and ways to provide effective treatments. In this study published in the journal Nanoscale, the Nanomedicine research group at INL, in collaboration with Stasiuk’s group at King’s College London, developed a new theranostic method for cancer treatment. Theranostics combines therapy and monitoring in a single formulation, offering a more personalised approach to treat cancer. INL researchers developed redox-responsive nanoparticles comprising manganese dioxide and a platinum prodrug, both intended to be activated specifically at the tumour microenvironment. Smart theranostic strategies, also known as responsive theranostics, are approaches in which the drug and/or imaging components are only activated or released in response to a certain stimulus. This stimulus can be a multitude of switches: light, magnetic fields, temperature, ultrasounds, or biological conditions such as the pH or redox state. For example, imagine a scenario where smart theranostic nanoparticles, which are temperature sensitive, are injected into the body, and they travel to a tumour site. When an external trigger, such as an alternating magnetic field or a laser, is […]

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INL continues to breakthrough in Energy research

INL continues to breakthrough in Energy research

Clean energy technologies based in photovoltaics, energy storage and renewable gases are key research lines of the Clean Energy Cluster at INL. In 2023 there were several developments in terms of people, projects, events, and scientific advances. There are 10 INL research groups participating in the Clean Energy cluster, with 17 research and development competitively funded projects, including 8 European projects. In 2023, these groups saw 5 PhD graduations and 9 MSc completions. Three researchers received recognition by Stanford University, placing them among the top 2% of scientists worldwide of 2022 – Laura Salonen, Lifeng Liu and Paulo Ferreira. INL hosted two relevant events, the Horizon Europe BATT4EU Funding Opportunities event, and organised a workshop within the FUNLAYERS twinning EU project. INL researchers in the Energy field developed new solutions, ranging from proof-of-concept to prototype devices for energy conversion, such as photovoltaic and renewable gases technologies, and energy storage, namely rechargeable batteries and hydrogen. Here one can have a glimpse of the research highlights in this field: The LaNaSC research group used conductive atomic force microscopy (C-AFM) tomography to investigate the impact of alkali-fluoride post-deposition treatments on Cu(In,Ga)Se2 (CIGS) solar cells. Their findings, published in Nature Energy, revealed that spatial inhomogeneities […]

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INL advances heavy metal detection in industrial wastewater

INL advances heavy metal detection in industrial wastewater

The advances in industrial modernisation are driving research towards the development of new sensors for the Industrial Internet of Things (IIoT) or Internet of Robotic Things (IoRT), aiming to enhance efficiency, production rates, and quality standards. However, current solutions face technical limitations in accuracy, and adaptability to real-world conditions. The Next-Gen Quality Control (NGQC) IoRT project focuses on developing an automated monitoring system to detect heavy metals in industrial effluents. This ecosystem includes environmental monitoring, as well as wastewater. Pilot testing is currently underway at Stellantis in Mangualde, embracing the principles of Industry 4.0. The monitoring system is integrated into a wastewater treatment plant to understand its evolution and whether water quality limits are being exceeded. Raquel Queirós, staff researcher in the Water Quality Group, explains, “This system collects a small sample from the tank at the beginning and end of the process. This sample is then filtered to detect the presence of the heavy metals”. Samuel Silva, research fellow in the Water Quality research group, adds, “The developed electrochemical sensors have been optimised to detect nickel and zinc.” The prototype has integrated an algorithm that calculates and estimates the concentration of the heavy metals. “The system is able to […]

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What is it like to be a woman working in STEAM (Science, Technology, Engineering, Arts, and Mathematics) fields?

What is it like to be a woman working in STEAM (Science, Technology, Engineering, Arts, and Mathematics) fields?

In the realm of Science, Technology, Engineering, Arts, and Mathematics (STEAM), the contributions of women have historically been undervalued and underrepresented. However, as the landscape of these fields continues to evolve, so too does the role of women within them. At INL – International Iberian Nanotechnology Laboratory, we believe in fostering an inclusive environment where all voices are heard and celebrated. To gain insight into the experiences of women working in STEAM fields at INL, we reached out to some of our esteemed female researchers. Their perspectives shed light on the challenges they’ve faced, the triumphs they’ve achieved, and the evolving dynamics within their respective disciplines. From groundbreaking scientific discoveries to innovative engineering solutions, these women are driving progress and shaping the future of STEAM. Join us as we celebrate the International Day of Women and Girls in Science, celebrated on 11 February, implemented by UNESCO and UN-Women and delve into the stories, insights, and aspirations of the remarkable women researchers at INL, highlighting their invaluable contributions and inspiring journeys in the world of STEAM. So… what is it like to be a woman working in STEAM (Science, Technology, Engineering, Arts, and Mathematics) fields? Alexandra TeixeiraAssociate • Medical DevicesIt means facing […]

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