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Intelligent biosensor developed at INL combines NMR and AI to improve infectious disease diagnostics

In the fight against infectious diseases, rapid and accurate diagnosis is key to effective treatment and control. INL researchers have developed a breakthrough biosensor that combines cutting-edge nuclear magnetic resonance (NMR) technology with artificial intelligence. This portable device not only speeds up diagnosis but also provides detailed insights into the immune response, opening new possibilities for point-of-care testing. The study, led by Juan Gallo and Weng Kung Peng published in the journal Biosensors and Bioelectronics, demonstrates how this innovative approach can detect viral infections and monitor patient recovery faster and more precisely than traditional methods, all within a compact, user-friendly system. The technology uses magnetic nanoparticles specifically designed to detect viral particles, as well as the immune response they trigger in the body. When these nanoparticles bind to target molecules in a small biological sample, they cause measurable changes in the sample’s magnetic properties. These changes are captured by the portable NMR system and translated into meaningful diagnostic information using machine learning models. “What sets this system apart is its ability to offer a more complete picture of the patient’s status,” explains Juan Gallo. “It doesn’t just tell you if someone is infected – it can help determine whether they […]

INL Welcomes Dr Cyril Laucci as Ombudsperson

The International Iberian Nanotechnology Laboratory is pleased to announce the appointment of Dr Cyril Laucci as Ombudsperson, a role that reflects the organisation’s ongoing commitment to fostering a respectful, fair, and inclusive environment. The Ombudsperson serves as a neutral, independent, and confidential resource available to all members of the INL community. The position is designed to promote fairness, transparency, and accountability across the organisation by addressing concerns, mediating disputes, encouraging respectful engagement, and advising on potential measures to resolve systemic challenges related to equity and inclusion. It is essential to emphasise that the Ombudsperson does not represent either the organisation or individual members of staff. Rather, the role functions as an impartial facilitator, supporting the informal resolution of issues and contributing to a constructive and healthy organisational culture. Dr Laucci is a highly distinguished legal professional with recognised expertise in human rights, workplace ethics, and international law. He holds a PhD in Law from both Université Aix-Marseille and the University of Geneva. Over the course of his career, he has held senior legal positions at several major international institutions, including the International Criminal Court (ICC), the International Criminal Tribunal for Rwanda, and the Special Court for Sierra Leone. On 22 […]

Interview with António Costa: Where 2D Materials Meet Quantum Innovation

Since earning his PhD in 1998, António Costa—Associate in the Rossier Research Group—has dedicated his research to the theoretical exploration of low-dimensional magnetic systems, with a particular emphasis on spin excitations. By combining analytical approaches with computational modeling, he investigates how magnetic materials respond to external influences such as magnetic fields and electrical currents, uncovering fundamental mechanisms that underpin their behavior. Your research focuses on 2D materials and the interface between plasmonics and magnonics. What recent breakthroughs stand out in your work?On the magnonics side, we have been studying the spin excitations of a new kind of magnetic materials called altermagnets. These have properties that are sort of in-between ferromagnets and antiferromagnets. We have demonstrated that the lifetime of magnons in metallic altermagnets can be highly anisotropic, a property that can be exploited technologically to guide magnons along certain paths in the material. Further details can be found in the publication here.On the magnonics/plasmonics interface, we have shown that graphene plasmons can couple strongly to the low-energy magnons in a 2D insulating ferromagnet, which can be uses as a new way to probe magnons in 2D materials, and also as a way to convert a magnetic into an electric signal and […]

INL Colloquia Series Explores Living Materials with Leading Researcher Dr. Anna Sandak

INL will host Dr. Anna Sandak as the featured speaker for the May edition of the INL Colloquia Series 2025. A leader in sustainable architecture and advanced materials, Dr. Sandak will share her visionary work on Engineered Living Materials (ELMs) — a new class of bio-integrated materials that bring adaptability, self-regeneration, and environmental responsiveness into the built environment. Her talk will highlight groundbreaking research from two major EU-funded projects: ARCHI-SKIN, which develops living coating systems for buildings using fungal biofilms, and REMEDY, a new initiative exploring bespoke, living layers for architecture — so-called archibiome tattoos — that blend aesthetics with functionality. By merging biotechnology with material science, Dr. Sandak’s work is redefining sustainability in architecture and opening the door to a future where buildings can grow, heal, and evolve with their surroundings. About Dr. Anna Sandak Dr. Sandak is the Deputy Director for Science and Head of the Materials Department at InnoRenew CoE in Slovenia, and an Associate Professor at the University of Primorska. With a strong background in biology and wood science, she has led over a dozen major research projects, including the ERC Consolidator Grant project ARCHI-SKIN and the EIC Pathfinder project REMEDY. Her research focuses on integrating living systems into construction materials to create eco-adaptive and regenerative buildings. About INL Colloquia Series 2025 The INL Colloquia Series 2025 is an inspiring monthly […]

Graphene-based biosensor breaks detection records for non-invasive monitoring of diabetes

A breakthrough biosensor detects glucose in human tears at ultra-low concentrations, opening new avenues for wearable health monitoring technologies. In a significant leap toward the future of diabetes care, INL researchers have developed a graphene-based biosensor capable of detecting glucose at attomolar levels—representing the lowest detection limits ever achieved for this crucial biomarker. It’s comparable to finding a single grain of sugar dissolved in an entire lake. The study, published in the Journal of the American Chemical Society and led by Dr. Andrea Capasso at INL, introduces an ultra-sensitive glucose sensor based on graphene field-effect transistor (GFET) technology. Engineered to operate with extremely small volumes of biological fluid – down to a single tear -, this device has the potential to revolutionise glucose monitoring, particularly in non-invasive and wearable systems. The researchers developed a targeted graphene functionalisation using glucose oxidase (GOx), enabling highly selective glucose recognition. They then employed advanced spectroscopic and microscopic techniques to analyse the graphene’s chemical composition and surface modifications at each stage of functionalisation, from enzyme immobilisation to interaction with the target analyte. “While finger-prick sensors remain the clinical standard for diabetes monitoring, they are often perceived as uncomfortable and invasive,” says Dr. Capasso. “Our goal […]

No assumptions: just quantum advantage

INL researcher Michael de Oliveira, together with collaborators from the University of Cambridge and the Hon Hai (Foxconn) Quantum Computing Research Center, has published a new article in Nature Communications demonstrating that even small, noisy quantum circuits can outperform certain types of classical computation, without relying on assumptions or ideal conditions. This study focuses on constant-depth quantum circuits, meaning that all operations happen in parallel in a very short time – like multiple people completing a task simultaneously rather than one after another. The researchers show that these simple quantum circuits can solve specific problems that no classical circuit of the same kind and size can solve, even when those classical circuits are modelled after neural networks, with tuneable flexibility. The classical models studied here (biased threshold circuits) are used in theoretical models of machine learning and resemble basic neural networks. Despite the authors considering versions with low bias – and therefore greater versatility – they are still outperformed by shallow quantum circuits, even when the quantum devices are noisy or imperfect. What makes this breakthrough particularly important is that it applies to qudits (quantum systems that go beyond binary bits or qubits), and the results are valid across all […]

Advancing neuronal research using 3D polymeric micro-scaffolds integrated with quantum sensors

A recent research study from INL has successfully merged two cutting-edge 3D tissue engineering strategies – 3D polymeric scaffolds and 3D neuronal spheroids – to create a highly advanced model for studying neuronal behaviour and disease. The collaboration between biomedical engineers, physicists, and neuroscientists has led to the development of a smart polymeric scaffold integrated with fluorescent nanodiamonds, that reveals to be a powerful quantum sensing tool. These low auto-fluorescence scaffolds, fabricated using laser-based 3D microprinting, were designed to be both biocompatible and capable of hosting 3D neuronal spheroids. The fluorescent nanodiamonds embedded within the scaffolds provide the potential for real-time monitoring of magnetic signals and temperature shifts at the nanoscale, providing a new level of precision in studying cellular signalling, disease mechanisms, and drug responses. Beatriz Costa, the first author of this study, emphasises the significance of the work: “The use of low-autofluorescence 3D polymeric scaffolds enabled the integration of quantum metrology techniques with nanodiamonds. When combined with 3D neuronal cell aggregates, this approach holds great potential for in-depth studies of neurodegenerative diseases and beyond.” The study’s success lies in its ability to use these scaffolds to host dopaminergic neurons, crucial to Parkinson’s disease research, and demonstrate the neurons’ […]

Portuguese Competence Centre for Semiconductors Launched at INL in Braga

The Portuguese Competence Centre for Semiconductors (POEMS) held its inaugural meeting yesterday, marking a significant milestone in the country’s semiconductor industry. Hosted by the International Iberian Nanotechnology Laboratory (INL), the launch session showcased the consortium’s key areas of expertise and strategic goals. Co-funded by Fundação para a Ciência e a Tecnologia (FCT) and the Chips Joint Undertaking – European Union, POEMS is set to become one of 27 European semiconductor competence centres. These centres aim to empower companies to advance semiconductor development, a critical component in the global technology landscape. POEMS, as a cutting-edge initiative under the Chips Joint Undertaking initiative, directly addresses the critical needs outlined in Axis 1 of the National Semiconductor Strategy. This strategic alignment aims to catapult Portugal to the forefront of semiconductor innovation and production, specifically focusing on microelectronics and semiconductors. These areas are pivotal for elevating the existing industrial and technological capacities to meet key global challenges. Focusing on the strategic areas of chip design, advanced packaging, and emerging semiconductor technologies, POEMS leverages the diverse expertise of its 16 consortium partners. These partners include leading research and academic institutions that bring specialised training resources and cutting-edge capabilities. In Portugal, the 16 POEMS partners will […]

INL Hosts IDEAL Cluster Annual Meeting in Portugal

The IDEAL Cluster for Indoor Air Quality and Health held its second Annual Meeting on March 25-26, 2025, in Braga, Portugal. The event aimed to enhance synergies and amplify the impact of various Horizon Europe projects focused on indoor air quality and health. This year’s meeting was hosted by the LEARN project at the International Iberian Nanotechnology Laboratory (INL), which coordinates the IDEAL Cluster from September 2024 to April 2025. The event saw the participation of around 50 researchers and R&I professionals representing seven projects and eight working groups, with additional attendees joining online. Among the on-site participants were 10 members from LEARN project partner organizations, including INL, FI Group, VUB, TU/e, MANN+HUMMEL, and NIA. They presented their advancements in air pollution sensors, in-vitro models, skin-on-a-chip, and multi-sensing approaches, along with preliminary results from cohorts at Belgian schools and notable communication activities. Key discussions and presentations covered policy recommendations on indoor air quality, data exchange practices, communication collaborations, innovative sensor developments, guidelines and standardisation efforts, and the potential creation of a global indoor air quality index. The European Commission was represented by project officer Rita Araújo from the DG for Research and Innovation, Marco Morini from the DG for Energy, […]

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INL in the Media

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