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INL researchers awarded funding to develop an automated sensor to detect emerging viruses

Zoonotic infectious diseases, i.e. diseases that transmit from animals to humans, are on the rise, and the potential for a new pandemic is more significant than ever. It is imperative to develop advanced technologies capable of continuous monitoring to identify high-risk zones for pathogen transmission between animals and humans. This requirement is essential to mitigate the potential human, socio-political, and economic impact of pandemics. The global initiative ‘One Health’ advocates collaboration among human, animal, and environmental health professionals to address health challenges. Its goal is to comprehend and prevent zoonotic diseases, while fostering a holistic approach to global health. Although the European Parliament calls for continuous surveillance and harmonised data collection from animal farms, current practices fall short for continuous and automatic detection, limiting detection to specific and already known pathogens. FLUFET, which stands for ‘FLow detection of virUses by graphene Field Effect Transistor microarrays’, is the new EIC Pathfinder project with a goal to develop a novel approach for the detection of viruses. It will be the first automated sensor capable of continuously detecting a broad spectrum of viral targets, including unknown viruses. This revolutionary sensor, combining technologies and knowledge from different fields, such as graphene field effect transistors […]

INL researchers innovating in next-generation solar power

Solar cells, also known as photovoltaic cells, directly convert sunlight into electricity. The most prevalent type, crystalline silicon photovoltaic cells, found in commercially available solar panels, benefit from extensive expertise and synergies with the microelectronics industry. Despite their cost competitiveness, silicon photovoltaic cells have limitations, such as poor sensitivity to low light, rigid modules, conservative aesthetics, and limited flexibility in dimensions. If photovoltaics are to be deployed in a larger number of applications, these limitations need to be addressed. The Nanofabrication, Optoelectronics, and Energy Applications (NOA) research group is exploring novel thin-film solar cell concepts – or next-generation photovoltaics – to enhance performance while meeting environmental standards. They are particularly focused on developing solutions that merge conversion efficiency, durability, and aesthetics for building-integrated photovoltaics (BIPV), targeting stakeholders in the construction industry. BIPV offers a practical means of integrating photovoltaic systems into buildings, potentially facilitating the installation of hundreds of gigawatts worldwide without the need for additional land. This approach aligns well with the current trend of urbanisation. Pedro Salomé, NOA’s group leader, elaborates “We are engaged in various projects, funded by Portuguese and European programmes, to devise solutions that overcome the challenges posed by conventional silicon modules. Most of our […]

A microfluidic platform that simulates human digestion

In a recently published study, INL researchers developed an innovative microfluidic platform that is capable of replicating key human gastrointestinal processes, offering a game-changing tool for the assessment of newly-developed drugs and/or food supplements. The innovation combines a ‘Digestion-Chip’ and a ‘Gut-Chip’, each enabling sequentially the simulation of digestion through the gastrointestinal tract and the evaluation of intestinal permeability. The study ‘From mouth to gut: microfluidic in vitro simulation of human gastro-intestinal digestion and intestinal permeability’, introduces a miniaturised setup that allows studies of sample bioaccessibility and simplified bioavailability using minimal sample amounts. In addition, the outflow from the ‘Digestion-chip’ can be exposed to the cell-based Gut-Chip, which replicates the intestinal epithelium, using unprecedentedly low sample dilutions thus allowing the detection of ‘rare’ compounds. Both devices work in continuous flow requiring very little user interfacing. In this work, casein – a milk protein that is widely used as a supplement in sports nutrition – was tested as a model compound. And critically, the Gut-Chip can be used to evaluate intestinal permeability offering reference permeability values that are in line to those found using human ex vivo models. Miguel Xavier, one of the first authors of the research study adds “the […]

Detecting objects without any physical interaction – reality or science fiction?

INL researchers have explored a fascinating quantum ability which lacks a classical explanation: the capacity to detect objects without traditional physical interaction. Rafael Wagner and Anita Camillini, INL PhD candidates, alongside the research group-leader Ernesto F. Galvão, have published a paper describing the revolutionary approach that challenges conventional concepts of detection. Imagine being able to identify something without actually touching it – similarly to diagnosis a hidden fracture without an X-ray or recognising a distant voice without hearing it directly. This study explores how quantum computers can achieve that, and detect objects without direct interaction. Rafael Wagner explains “It has been known for a long time that it is possible to detect things without interactions, as a result of the famous thought experiment introduced by Elitzur and Vaidman. They imagined an extreme situation where either there is a bomb in one of the arms of an interferometer, or there is no bomb.” Interferometers are tools used in many fields of science and engineering. The working principle of interferometry consists on splitting the light into two beams that travel different optical paths and are then combined to produce an interference pattern. Their scenario presents an unusual premise: within an interferometer setup, […]

Is greenhouse farming releasing microplastics into water?

In a recent study conducted by INL researchers, in collaboration with University of Alcalá, Madrid, it has been revealed that greenhouse plastic cover films, commonly composed of polyethylene (PE), are releasing microplastics into the environment during their usage, significantly impacting ecosystems. Microplastics are tiny plastic particles that can result from commercial product development or from the breakdown of larger plastics, and may take hundreds or thousands of years to decompose. Microplastics, defined as plastic particles smaller than 5 millimeters, and nanoplastics, typically smaller than 1 micrometre, have been identified in various ecosystems, including water bodies, soil, and even food and beverages. Their ability to penetrate biological barriers and interact with organisms raises significant concerns about their long-term impacts on biodiversity and human health. The study was conducted over a six-month period in Almeria, Spain, where extensive greenhouse farming is practiced, to better understand the consequences of plastic degradation. Most vegetables grown in these greenhouses are sown and harvested within 6 months, and water analysis was performed at several time points. Researchers from the Water Quality research group at INL and the University of Alcalá applied advanced characterisation techniques to assess the chemical fingerprint, size distribution, and concentration of plastic particles released […]

Nanotechnology for predicting and preventing seizures in neurological diseases

INL researchers are part of the European consortium CROSSBRAIN – a groundbreaking project aimed at developing microbots to predict and prevent seizures in individuals suffering from conditions such as epilepsy or Alzheimer’s disease. Within the complexity of our brains, neurons communicate through various signalling mechanisms, including chemical, thermal, and electrical changes. Many neurological disorders affecting the brain originate from abnormal electrical activity, leading to conditions such as epileptic seizures. When these abnormalities in electrical activity occur, prompt identification and swift intervention are vital for effective treatment. However, current technologies for monitoring and modulating brain activity with precision are very limited. CROSSBRAIN brings together leading researchers from across Europe to develop a new solution for predicting and preventing seizures in neurological conditions. Coordinated by researchers from Tor Vergata University of Rome, the consortium aims to create micro-sized robots that can be implanted in our brains. By combining cutting-edge computing and nanomaterials, CROSSBRAIN will enable precise modulation of brain tissue using various stimulation methods, including electrical, mechanical, thermal, and optical principles. The microbots, powered wirelessly by a compact central unit, will then be implanted through blood vessels, with the capability to deliver genetic material. Once integrated into the network of neurons, these […]

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