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Graphene-based biosensor breaks detection records for non-invasive monitoring of diabetes

A breakthrough biosensor detects glucose in human tears at ultra-low concentrations, opening new avenues for wearable health monitoring technologies. In a significant leap toward the future of diabetes care, INL researchers have developed a graphene-based biosensor capable of detecting glucose at attomolar levels—representing the lowest detection limits ever achieved for this crucial biomarker. It’s comparable to finding a single grain of sugar dissolved in an entire lake. The study, published in the Journal of the American Chemical Society and led by Dr. Andrea Capasso at INL, introduces an ultra-sensitive glucose sensor based on graphene field-effect transistor (GFET) technology. Engineered to operate with extremely small volumes of biological fluid – down to a single tear -, this device has the potential to revolutionise glucose monitoring, particularly in non-invasive and wearable systems. The researchers developed a targeted graphene functionalisation using glucose oxidase (GOx), enabling highly selective glucose recognition. They then employed advanced spectroscopic and microscopic techniques to analyse the graphene’s chemical composition and surface modifications at each stage of functionalisation, from enzyme immobilisation to interaction with the target analyte. “While finger-prick sensors remain the clinical standard for diabetes monitoring, they are often perceived as uncomfortable and invasive,” says Dr. Capasso. “Our goal […]

Registrations Now Open for INL Open Day 2025

Step Inside the Future of Science – May 31, 2025 | Braga, Portugal The International Iberian Nanotechnology Laboratory (INL) invites the public to a unique and immersive journey into the world of science and innovation at the INL Open Day 2025, taking place on Saturday, May 31, in Braga, Portugal. For one day only, INL opens its doors to curious minds of all ages — offering a rare glimpse inside one of Europe’s leading research centres in nanotechnology. Visitors will have the opportunity to explore cutting-edge laboratories, interact with world-class researchers, and experience how science is shaping a more sustainable and connected future. From interactive experiments and artistic installations to live performances and family-friendly workshops, the event promises to ignite curiosity and celebrate the power of discovery. Highlights include: Participation is free of charge, but registration is required to ensure access to guided tours and hands-on activities. 📍 Join us at INL, Braga | 🗓️ Saturday, 31 May 2025 Reserve your spot now! Let’s explore the future of science — together. + REGISTER + PROGRAMME

No assumptions: just quantum advantage

INL researcher Michael de Oliveira, together with collaborators from the University of Cambridge and the Hon Hai (Foxconn) Quantum Computing Research Center, has published a new article in Nature Communications demonstrating that even small, noisy quantum circuits can outperform certain types of classical computation, without relying on assumptions or ideal conditions. This study focuses on constant-depth quantum circuits, meaning that all operations happen in parallel in a very short time – like multiple people completing a task simultaneously rather than one after another. The researchers show that these simple quantum circuits can solve specific problems that no classical circuit of the same kind and size can solve, even when those classical circuits are modelled after neural networks, with tuneable flexibility. The classical models studied here (biased threshold circuits) are used in theoretical models of machine learning and resemble basic neural networks. Despite the authors considering versions with low bias – and therefore greater versatility – they are still outperformed by shallow quantum circuits, even when the quantum devices are noisy or imperfect. What makes this breakthrough particularly important is that it applies to qudits (quantum systems that go beyond binary bits or qubits), and the results are valid across all […]

Advancing neuronal research using 3D polymeric micro-scaffolds integrated with quantum sensors

A recent research study from INL has successfully merged two cutting-edge 3D tissue engineering strategies – 3D polymeric scaffolds and 3D neuronal spheroids – to create a highly advanced model for studying neuronal behaviour and disease. The collaboration between biomedical engineers, physicists, and neuroscientists has led to the development of a smart polymeric scaffold integrated with fluorescent nanodiamonds, that reveals to be a powerful quantum sensing tool. These low auto-fluorescence scaffolds, fabricated using laser-based 3D microprinting, were designed to be both biocompatible and capable of hosting 3D neuronal spheroids. The fluorescent nanodiamonds embedded within the scaffolds provide the potential for real-time monitoring of magnetic signals and temperature shifts at the nanoscale, providing a new level of precision in studying cellular signalling, disease mechanisms, and drug responses. Beatriz Costa, the first author of this study, emphasises the significance of the work: “The use of low-autofluorescence 3D polymeric scaffolds enabled the integration of quantum metrology techniques with nanodiamonds. When combined with 3D neuronal cell aggregates, this approach holds great potential for in-depth studies of neurodegenerative diseases and beyond.” The study’s success lies in its ability to use these scaffolds to host dopaminergic neurons, crucial to Parkinson’s disease research, and demonstrate the neurons’ […]

Portuguese Competence Centre for Semiconductors Launched at INL in Braga

The Portuguese Competence Centre for Semiconductors (POEMS) held its inaugural meeting yesterday, marking a significant milestone in the country’s semiconductor industry. Hosted by the International Iberian Nanotechnology Laboratory (INL), the launch session showcased the consortium’s key areas of expertise and strategic goals. Co-funded by Fundação para a Ciência e a Tecnologia (FCT) and the Chips Joint Undertaking – European Union, POEMS is set to become one of 27 European semiconductor competence centres. These centres aim to empower companies to advance semiconductor development, a critical component in the global technology landscape. POEMS, as a cutting-edge initiative under the Chips Joint Undertaking initiative, directly addresses the critical needs outlined in Axis 1 of the National Semiconductor Strategy. This strategic alignment aims to catapult Portugal to the forefront of semiconductor innovation and production, specifically focusing on microelectronics and semiconductors. These areas are pivotal for elevating the existing industrial and technological capacities to meet key global challenges. Focusing on the strategic areas of chip design, advanced packaging, and emerging semiconductor technologies, POEMS leverages the diverse expertise of its 16 consortium partners. These partners include leading research and academic institutions that bring specialised training resources and cutting-edge capabilities. In Portugal, the 16 POEMS partners will […]

INL Colloquia Series Welcomes Prof. Dr. Max Lemme for a Groundbreaking Talk on 2D Materials

The INL Colloquia Series is thrilled to announce that Prof. Dr. Max Lemme, a leading figure in the field of nanoscale transistors and 2D materials, will be delivering a talk titled “Device Applications of 2D Materials“ on 23 April 2025 at 15:00 at INL – International Iberian Nanotechnology Laboratory, in Braga – Portugal. This event promises to be a highlight of the series, offering insights into cutting-edge research and its applications in communication, sensing, and neuromorphic computing. Prof. Dr. Lemme is at the forefront of the NeuroSys future cluster, an ambitious project focused on Neuromorphic Hardware for Autonomous Artificial Intelligence Systems. NeuroSys, one of seven future clusters selected for funding from over 130 submissions in the Clusters4Future initiative by the Federal Ministry of Education and Research (BMBF), aims to develop innovative hardware for AI applications and position the Aachen region as a global leader in this field. This talk is a unique opportunity to hear from a pioneer in the field and to learn about the latest advancements in 2D materials and their potential to revolutionize technology. About the INL Colloquia Series 2025 The INL Colloquia Series 2025 is an inspiring monthly event that delves into cutting-edge science and engineering. Now in […]

INL Hosts IDEAL Cluster Annual Meeting in Portugal

The IDEAL Cluster for Indoor Air Quality and Health held its second Annual Meeting on March 25-26, 2025, in Braga, Portugal. The event aimed to enhance synergies and amplify the impact of various Horizon Europe projects focused on indoor air quality and health. This year’s meeting was hosted by the LEARN project at the International Iberian Nanotechnology Laboratory (INL), which coordinates the IDEAL Cluster from September 2024 to April 2025. The event saw the participation of around 50 researchers and R&I professionals representing seven projects and eight working groups, with additional attendees joining online. Among the on-site participants were 10 members from LEARN project partner organizations, including INL, FI Group, VUB, TU/e, MANN+HUMMEL, and NIA. They presented their advancements in air pollution sensors, in-vitro models, skin-on-a-chip, and multi-sensing approaches, along with preliminary results from cohorts at Belgian schools and notable communication activities. Key discussions and presentations covered policy recommendations on indoor air quality, data exchange practices, communication collaborations, innovative sensor developments, guidelines and standardisation efforts, and the potential creation of a global indoor air quality index. The European Commission was represented by project officer Rita Araújo from the DG for Research and Innovation, Marco Morini from the DG for Energy, […]

Rui Campos Advances Biosensor Research at INL

Rui Campos, working in the Diéguez Research Group at INL – International Iberian Nanotechnology Laboratory since October 2024, is developing a biosensor for continuous detection of inflammation biomarkers as part of the WINGS project funded by the La Caixa Foundation – Health Research Programme. His research focuses on bioelectrochemical assays for detecting nucleic acids, proteins, and small molecules. Dr. Campos earned his Ph.D. in Chemistry from Durham University (UK) in 2013. He has conducted postdoctoral research at Aarhus University (Denmark), INL (Portugal), and the University of Antwerp (Belgium), where he developed a biosensor for prostate cancer microRNAs under the Marie Skłodowska-Curie Actions fellowship. In this interview, Dr. Campos shares his journey in biosensor research, contributions to the WINGS project, and advice for young researchers in nanotechnology and biomedical applications. What drew you to biosensor research, and how has your journey across different institutions shaped your expertise? My interest in biosensor research was sparked by the potential to create innovative solutions for real-world problems, particularly in healthcare. The ability to develop devices that can detect and monitor biological markers with high sensitivity and specificity is incredibly exciting.My journey across different institutions has been instrumental in shaping my expertise. At Durham, UK, […]

INL Presents Falling Walls Lab Portugal: A Premier Pitch Competition for Innovators

The International Iberian Nanotechnology Laboratory (INL) is excited to announce that it will host the Falling Walls Lab Portugal on June 11, 2025, in Braga. This prestigious event is part of a global series of pitch competitions and networking forums designed to showcase breakthrough ideas from students and early-career professionals. Falling Walls Lab provides a unique platform for participants to present their innovative solutions to some of the world’s most pressing challenges. Each participant has just three minutes to impress a distinguished jury, their peers, and the general public with their ideas. The competition not only highlights the quality and diversity of regional talent but also fosters collaboration and enhances participants’ communication skills. Winners from each international Falling Walls Lab event earn a coveted spot in the global finale in Berlin on November 7, 2025. They will also receive a ticket to the prestigious Falling Walls Science Summit, offering unparalleled networking opportunities with leaders in science, business, and policymaking. Applications for Falling Walls Lab Portugal are now open and can be submitted via www.falling-walls.com/lab/apply. The deadline for applications is May 4, 2025 May 12, 2025. Students and early-career professionals are encouraged to apply and seize this opportunity to drive their […]

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INL in the Media

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