Alfaro-Moreno Group
The group was launched with the support of an ERA-Chair grant entitled SiNfONiA – Safety in Nanomaterials & Nanotechnology. The overall aim of SiNfONiA is to boost RTD activities in the nanosafety arena and strengthen the research and innovation potential of INL.
Research Lines:
- Organ-on-a-chip technology to evaluate the safety of nanomaterials used on products that could get in contact with the skin or the respiratory tract.
- Epigenetics and in vitro/in vivo bridging models to evaluate the safety of different nanomaterials and pollutants.
- Toxicology and immunotoxicology of nanomaterials using sensors and high-throughput technologies.
- In silico evaluations using QSAR, QSPR, QSTR, machine learning and life cycle assessment.
Projects
Publications
-
Decoding the conformational binding of drug mixtures on ovalbumin: An integrated multimodal network.
International Journal of Biological Macromolecules, 2024Differential DNA methylation and metabolite profiling of Atlantic killifish (Fundulus heteroclitus) from the New Bedford Harbor Superfund site
ECOTOXICOLOGY, 2024 -
Ambient black carbon particles in human ovarian tissue and follicular fluid
ENVIRONMENT INTERNATIONAL, 2023Revealing the binding dynamics between catanionic surfactants and lysozyme: A synergistic computational approach coupled with experimental validation.
Journal of Molecular Liquids, 2023Microfluidic-based skin-on-chip systems for safety assessment of nanomaterials
TRENDS IN BIOTECHNOLOGY, 2023A Nano-QSTR model to predict nano-cytotoxicity: an approach using human lung cells data
PARTICLE AND FIBRE TOXICOLOGY, 2023In Vitro Cell Transformation Assays: A Valuable Approach for Carcinogenic Potentiality Assessment of Nanomaterialsned...
International Journal of Molecular Sciences, 2023Titanium dioxide nanoparticles affect osteoblast-derived exosome cargos and impair osteogenic differentiation of human mesenchymal stem cells
BIOMATERIALS SCIENCE, 2023To be defMixture and individual effects of benzene, toluene, and formaldehyde in zebrafish (Danio rerio) development: Metabolomics, epigenetics, and behavioral approaches
Environmental Toxicology and Pharmacology 97: 104031, 2023The Effects of Titanium Dioxide Nanoparticles on Osteoblasts Mineralization: A Comparison between 2D and 3D Cell Culture Models
NANOMATERIALS, 2023The system of self-consistent models based on quasi-SMILES as a tool to predict the potential of nano-inhibitors of human lung carcinoma cell line A549 for different experimental conditions
DRUG AND CHEMICAL TOXICOLOGY, 2023 -
To be defined...
, 2021 -
Effectiveness and Safety of a Nontargeted Boost for a CXCR4-Targeted Magnetic Hyperthermia Treatment of Cancer Cells
ACS OMEGA, 2019Portable sensing system based on electrochemical impedance spectroscopy for the simultaneous quantification of free and total microcystin-LR in freshwaters
BIOSENSORS & BIOELECTRONICS, 2019Rutile nano-bio-interactions mediate dissimilar intracellular destiny in human skin cells
Nanoscale advances 1 (2019) 2216-2228, 2019 -
Combining CXCR4-targeted and nontargeted nanoparticles for effective unassisted in vitro magnetic hyperthermia
BIOINTERPHASES, 2018Green synthesis of fluorescent carbon dots from spices for in vitro imaging and tumour cell growth inhibition
BEILSTEIN JOURNAL OF NANOTECHNOLOGY, 2018 -
Targeting chemokine receptor CXCR4 with magnetic particles to eliminate leukaemia cells with magnetic hyperthermia
TOXICOLOGY LETTERS, 2016Performance enhanced UV/vis spectroscopic microfluidic sensor for ascorbic acid quantification in human blood
BIOSENSORS & BIOELECTRONICS, 2016