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A microfluidic platform that simulates human digestion

In a recently published study, INL researchers developed an innovative microfluidic platform that is capable of replicating key human gastrointestinal processes, offering a game-changing tool for the assessment of newly-developed drugs and/or food supplements. The innovation combines a ‘Digestion-Chip’ and a ‘Gut-Chip’, each enabling sequentially the simulation of digestion through the gastrointestinal tract and the evaluation of intestinal permeability. The study ‘From mouth to gut: microfluidic in vitro simulation of human gastro-intestinal digestion and intestinal permeability’, introduces a miniaturised setup that allows studies of sample bioaccessibility and simplified bioavailability using minimal sample amounts. In addition, the outflow from the ‘Digestion-chip’ can be exposed to the cell-based Gut-Chip, which replicates the intestinal epithelium, using unprecedentedly low sample dilutions thus allowing the detection of ‘rare’ compounds. Both devices work in continuous flow requiring very little user interfacing. In this work, casein – a milk protein that is widely used as a supplement in sports nutrition – was tested as a model compound. And critically, the Gut-Chip can be used to evaluate intestinal permeability offering reference permeability values that are in line to those found using human ex vivo models. Miguel Xavier, one of the first authors of the research study adds “the […]

12th SciComPt Congress in Braga

In the pursuit of an inclusive scientific landscape, the 12th Congress of the SciComPt network will convene between May 8-10, 2024, in Braga, Portugal. Themed “Accessibility in Science Through Diverse Languages and Voices”, this landmark event aims to address the pressing need for enhanced accessibility in science communication. In today’s society, the responsibility of science extends beyond the laboratory walls. Merely providing access to scientific publications falls short of empowering citizens to fully engage with scientific knowledge. As science delves into increasingly complex and ethically nuanced realms, it becomes imperative to bridge the gap between scientific expertise and public understanding. Recognizing this imperative, the Congress will spotlight the critical role of science communication in fostering a more inclusive scientific community. From promoting ongoing dialogue between scientists and society to addressing sensory limitations and diversifying communication channels, Congress will delve into multifaceted strategies to enhance accessibility in science. The event will happen at INL – International Iberian Nanotechnology Laboratory, Centro Ciência Viva de Braga, and the University of Minho, and will serve as a platform for interdisciplinary dialogue, collaboration and will share insights, best practices, and innovative approaches to science communication between researchers, policymakers, communication professionals, and engaged citizens. With a […]

MAY 15: European Neuromorphic Computing Event Aims to Bridge Gap Between Research and Innovation

In a bid to foster collaboration and innovation in the field of neuromorphic computing, the INL – International Iberian Nanotechnology Laboratory is set to host a one-day research event bringing together coordinators, participants, and collaborators from various European projects and industry partners. Scheduled to take place on May 15, in Braga – Portugal, the event will serve as a platform for representatives from ten ongoing European research projects on neuromorphic computing. Additionally, two representatives from leading companies leveraging neuromorphic computing in their technologies will be in attendance. The event aims to stimulate discussion on bridging the gap between scientifically sound technologies and practical innovation in neuromorphic computing. By merging discussions on technologies at different stages of maturity, the organizers hope to identify common approaches and best practices for advancing these technologies in Europe. Key topics of discussion will include exploring available tools and addressing challenges that artificial neural networks and systems face in the realm of neuromorphic computing. Representative examples from participating projects will cover a spectrum of neuromorphic approaches, including electronics, spintronics, photonics, and other emerging materials often integrated with CMOS. These technologies find applications in diverse fields such as computer vision, edge AI, sensing, computing, high-frequency data processing, […]

Detecting objects without any physical interaction – reality or science fiction?

INL researchers have explored a fascinating quantum ability which lacks a classical explanation: the capacity to detect objects without traditional physical interaction. Rafael Wagner and Anita Camillini, INL PhD candidates, alongside the research group-leader Ernesto F. Galvão, have published a paper describing the revolutionary approach that challenges conventional concepts of detection. Imagine being able to identify something without actually touching it – similarly to diagnosis a hidden fracture without an X-ray or recognising a distant voice without hearing it directly. This study explores how quantum computers can achieve that, and detect objects without direct interaction. Rafael Wagner explains “It has been known for a long time that it is possible to detect things without interactions, as a result of the famous thought experiment introduced by Elitzur and Vaidman. They imagined an extreme situation where either there is a bomb in one of the arms of an interferometer, or there is no bomb.” Interferometers are tools used in many fields of science and engineering. The working principle of interferometry consists on splitting the light into two beams that travel different optical paths and are then combined to produce an interference pattern. Their scenario presents an unusual premise: within an interferometer setup, […]

INL hosts the 3-Minute Thesis competition, showcasing Doctoral Research talent

Last week, INL organised its highly anticipated Three Minute Thesis (3MT) competition, providing an exciting showcase of doctoral research excellence. The 3MT is an initiative that celebrates the exciting research conducted by INL PhD candidates. The 3MT aims to develop early stage researchers’ presentation and research communication skills. It provides support for PhD candidates to effectively explain their research and its significance in just three minutes, using language suitable for a non-specialist audience. Embracing the challenge of condensing months/years of rigorous study into a mere three minutes, 24 PhD candidates from diverse research areas at INL stepped up to the INL auditorium, aiming to captivate the audience of 100+ attendees. The three rounds were held on March 26th, 27th, and 28th. After intense deliberation, the top five candidates were nominated, with their presentations showcasing both academic rigor and compelling storytelling. Alexandra Alves, PhD candidate in the Quantum and Linear-Optical Computation group, highlighted the significance of accessible science communication, stating, “As PhD students we often present our work to expert audiences, but more approachable science communication is lacking. So it was both challenging and fun to try to condense my research topic into 3 minutes and for a diverse crowd.” For […]

INL Opens its doors to the public for a day of scientific exploration – #INLOPENDAY2024

INL – International Iberian Nanotechnology Laboratory invites you to a day of discovery and exploration on May 18, 2024, in Braga, Portugal. This exclusive event offers a unique opportunity to experience firsthand the cutting-edge research and innovation happening within our renowned institution. Visitors will have the chance to meet our esteemed researchers and delve into the fascinating world of nanotechnology. Explore our state-of-the-art facilities, interact with our scientists, and learn about the groundbreaking projects shaping the future of science and technology. At INL, we believe in the power of collaboration and community. This event not only showcases our commitment to excellence in research but also serves as a platform to strengthen our ties with the communities we serve. We extend our heartfelt gratitude to all those who join us on this exceptional day of scientific discovery. Together, let us embark on a journey into the realm of science, where possibilities are boundless and innovation knows no bounds. For more information and to register for this event, please click here. Don’t miss this opportunity to be part of an enriching and inspiring experience at INL – International Iberian Nanotechnology Laboratory. We look forward to welcoming you!

INL Hosts Open Session to Explore Breakthroughs in Single-Cell Analysis for Personalized Oncology

On April 4th, INL – International Iberian Nanotechnology Laboratory, in collaboration with the BIOCELLPHE project, is set to host an Open Session focused on pioneering advancements in single-cell analysis. This exclusive event presents a platform to delve into the challenges and opportunities within the field of single-cell analysis. Participants will have the opportunity to engage in discussions with leading experts and researchers, exploring the potential impact of these advancements on personalized oncology. INL’s partnership in the BIOCELLPHE project underscores its commitment to driving innovation and fostering collaboration at the forefront of nanotechnology research. By hosting this Open Session, INL aims to facilitate knowledge exchange and stimulate dialogue among stakeholders invested in the future of healthcare and diagnostics. Don’t miss this opportunity to be part of a transformative discussion on the cutting-edge developments in single-cell analysis for personalized oncology. Join us at INL on April 4th and be a part of shaping the future of healthcare. BIOCELLPHE, a project funded by the European Union’s Horizon 2020 FET-OPEN programme under Grant Agreement No #965018, aims to revolutionize the identification of proteins as diagnostic biomarkers at the single-cell level, boasting unparalleled sensitivity, multiplexing capabilities, and portability. Registration for the event is now open. […]

Roma Raj, integrating solar textiles into automotive design

Our goal is to highlight the outstanding accomplishments of women at INL across a range of fields and career phases. Come join us as we commemorate their successes, tell their stories, and ignite inspiration for the next generation of female scientists. Meet Roma Raj, Research Fellow at INL – International Iberian Nanotechnology Laboratory, working in the Nanochemistry Research Group, a group focused on the development of nanomaterials following the strategy CSI: Catalysis, Synthesis and Investigation. Roma, can you tell us a bit about your path and your main area of work? My career journey has been quite fascinating, moving from earning an M.Tech in Energy Engineering to obtaining a Ph.D. in Chemical Engineering. Along the way, I’ve developed a deep passion and expertise in sustainable energy solutions, particularly in blending innovative technologies with environmental awareness. Currently, I’m focused on an exciting project: seamlessly integrating solar textiles into automotive design. This ground-breaking effort has great potential to transform how we view transportation and its effects on our planet. What is the importance of your work, and your research? The work I’m involved in is tackling one of humanity’s biggest challenges: climate change. By leading the way in integrating solar textiles into automotive, we’re […]

Nanotechnology for predicting and preventing seizures in neurological diseases

INL researchers are part of the European consortium CROSSBRAIN – a groundbreaking project aimed at developing microbots to predict and prevent seizures in individuals suffering from conditions such as epilepsy or Alzheimer’s disease. Within the complexity of our brains, neurons communicate through various signalling mechanisms, including chemical, thermal, and electrical changes. Many neurological disorders affecting the brain originate from abnormal electrical activity, leading to conditions such as epileptic seizures. When these abnormalities in electrical activity occur, prompt identification and swift intervention are vital for effective treatment. However, current technologies for monitoring and modulating brain activity with precision are very limited. CROSSBRAIN brings together leading researchers from across Europe to develop a new solution for predicting and preventing seizures in neurological conditions. Coordinated by researchers from Tor Vergata University of Rome, the consortium aims to create micro-sized robots that can be implanted in our brains. By combining cutting-edge computing and nanomaterials, CROSSBRAIN will enable precise modulation of brain tissue using various stimulation methods, including electrical, mechanical, thermal, and optical principles. The microbots, powered wirelessly by a compact central unit, will then be implanted through blood vessels, with the capability to deliver genetic material. Once integrated into the network of neurons, these […]

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