News

Researchers achieve quantum breakthrough with novel quantum-to-quantum Bernoulli factory design

Unlike classical computers, which use bits to process information as either 0s or 1s, quantum computers use quantum bits, also known as qubits, which can represent and process both 0 and 1 simultaneously thanks to a quantum property called superposition. This fundamental difference gives quantum computers the potential to solve some complex problems much more efficiently than classical computers. INL researcher Ernesto Galvão, in collaboration with Sapienza Università di Roma (Rome) and Istituto di Fotonica e Nanotecnologie (Milan), recently published a groundbreaking study in the journal Science Advances, where they describe a new set-up for a quantum-to-quantum Bernoulli factory. A Bernoulli factory is a method to manipulate randomness, using as inputs random coin flips with a certain probability distribution, and outputting coin flips with a different, desired distribution. Let us imagine we have a coin that lands on heads with some unknown probability. Now, we want to create a new coin that lands on heads with a different probability, possibly described by a function of the initial probability. The Bernoulli factory is an ingenious way to flip our original coin multiple times and use the different outcomes to simulate the new coin with the desired probability. Ernesto Galvão adds “This […]

Instruct Hands-on Workshop

The Instruct Hands-on Workshop, held from October 7 to 10, 2024, is set to provide in-depth training on sample preparation for single particle analysis (SPA) by cryo-electron microscopy (cryo-EM). The workshop, hosted by a team of experts from ITQB NOVA, INL, and CNB–CSIC, aims to equip participants with best practices and the latest techniques in cryo-EM imaging. Participants will engage in a comprehensive course featuring a blend of lectures and hands-on tutorials. The lectures will delve into the principles of SPA, covering theoretical and practical aspects of preparing biological samples for negative staining and quality assessment. Practical sessions will offer hands-on experience with vitrification using a plunge-freezing device and optimising grids for sample screening with a cryo-transmission electron microscope (TEM). Attendees are encouraged to bring their samples, providing a unique opportunity to apply newly acquired skills to their specific research needs. The workshop will highlight recent advancements in protein production and stabilisation, as well as the latest technological innovations in grid preparation and sample manipulation. This integrative approach will be crucial for addressing challenging scientific projects. The workshop aims to provide participants with a holistic understanding of the integrated use of biophysics, biochemistry, and cryo-EM for protein structure determination and analysis. […]

Researchers Inspire Young Minds at Schools

As part of the European Researchers’ Night initiative, researchers visited several schools in the summer camp program in Tadim-Braga to promote science and engage young students. These visits are part of the ongoing efforts to celebrate science and bring it closer to citizens, aligning with ERN’s 2024-2025 theme of “Science for Global Challenges.” July 4: Engaging the Young MindsOn July 4, a team of INL researchers, including Catarina Moura, Carlos Honrado, Adriana Carneiro, Bernardo Nogueira, Maria Relvas, and Tiago Moura, prepared different experiences for students of EB1 Tadim, EB2,3 Tadim, and Alfacoop schools. 45 students participated and built on their knowledge and interest in scientific topics. The activities conducted were designed to illustrate how science can address major global and European challenges in environmental, economic, and social sustainability. July 18: Continuing the Journey of DiscoveryOn July 18, researchers João Henriques, João Rodrigues, Lurdes Gonçalves, Diana Oliveira, Mariam Debs, Carlos Rosário, and Catarina Moura prepared different experiences, once again, for students of EB1 Tadim, EB2,3 Tadim, and Alfacoop schools. Students, aged between 4 to 14, participated in interactive sessions that sparked their curiosity and enthusiasm for science. These activities were tailored to suit the varied age groups, ensuring that each student […]

Can we cut the energy consumption of current AI technologies?

As artificial intelligence, commonly referred to as AI, becomes increasingly integrated into various aspects of our daily lives, the energy demands of AI systems continue to rise. Despite AI being inspired by the human brain, it is significantly less energy efficient because most tasks are implemented on computer hardware that is not specifically tailored for this purpose. The human brain remains an exemplar of energy-efficient computation, a standard that modern technology strives to replicate. INL researchers are studying advanced materials and devices aimed at revolutionising AI systems. Carlos Rosário, ERA fellow at INL (Marie Skłodowska-Curie actions (MSCA)), focuses his research on reducing the substantial energy consumption required by current AI technologies. Carlos’ work is grounded in the field of neuromorphic computing, which seeks to mimic the brain’s intricate network of neurons and synapses using artificial equivalents. The goal is to create an electronic brain capable of performing complex computations with minimal energy use. One of the key areas of Carlos Rosário’s research is the exploration of 3D topological insulators for novel electronic devices. These cutting-edge materials exhibit unique properties: while they are insulators and do not conduct electricity through their bulk, their surfaces behave like metals, allowing for efficient electrical […]

Secretary of State for Science Visits INL, Showcasing Key Projects and Innovations

Prof. Dr Ana Paiva, Secretary of State for Science, visited INL – International Iberian Nanotechnology Laboratory today. This visit provided an exceptional platform for INL to present its ongoing projects and significant achievements in the field of science and technology. The presence of Prof. Dr. Paiva underscored the crucial role of INL’s work and its far-reaching impact on the broader scientific community. Prof. Dr. Clivia M. Sotomayor Torres, INL Director-General, welcomed Prof. Dr Paiva and provided an insightful overview of INL’s mission and accomplishments. This introduction set the stage for a series of detailed presentations and discussions that highlighted INL’s prominence in both the national and European research landscapes. Presentation Highlights: Secretary of State’s visit to INL was a testament to the laboratory’s dedication to innovation, excellence, and its significant contributions to the field of science and technology. This visit not only highlighted INL’s achievements but also reinforced the importance of continued support and investment in scientific research and development. Text and Photography by Gina Palha

Breakthrough technology for cancer diagnostics

INL researchers are part of the consortium behind BIOCELLPHE, a pioneering project focused on advancing cancer diagnostics and personalised medicine. This innovative European-funded project is at the forefront of scientific and technological innovation, introducing a groundbreaking technology for identifying proteins as diagnostic biomarkers at the single-cell level. This new approach offers multiplexing capabilities, portability and enhanced sensitivity. Alexandra Teixeira, research fellow at the Medical Devices group, highlights that “BIOCELLPHE is pioneering the use of engineered bacteria to recognise and bind with high specificity to protein targets on the surface of circulating tumour cells, or CTCs, which are key players in cancer metastasis.” This specific binding of engineered bacteria to CTCs subsequently triggers the production of molecules (Raman reporters), which can be detectable with high sensitivity using surface-enhanced Raman scattering (SERS). More specifically, SERS uses plasmonic nanoparticles to enhance Raman signals, allowing ultrasensitive analysis and detection at the single molecule level. The pathological role of CTCs in cancer metastasis is not completely understood due to the lack of effective analytical tools and remains an area that needs further exploration. BIOCELLPHE addresses this gap by developing new tools for the phenotypic identification of CTCs at the single-cell level, with high-throughput and multiplexing […]

INL volta abrir as portas à sociedade

A miniaturised model of human digestion to advance therapies and nutritional products

INL researchers have made a significant breakthrough in the development of reliable in-vitro digestion models. This ‘digestion-chip’ promises to revolutionise the way new oral formulations are tested, offering a more accurate, efficient, and cost-effective alternative to current models. Traditional in-vitro digestion models often fail to replicate the complex dynamics of the human gastrointestinal tract. They either lack critical digestive processes or require large volumes of samples and reagents, which can be challenging when dealing with nanomaterials. The INL’s innovative ‘digestion-chip’ addresses these limitations with its miniaturised design and advanced features. The coordinator of the study Catarina Gonçalves explains, “the Food Processing and Nutrition research group proposes a miniaturised digestion system based on incubation chambers integrated into a polymethylmethacrylate device. This solution incorporates key dynamic features of human digestion while maintaining low complexity and using small volumes of samples and reagents”. The digestion-chip features gradual acidification (the stepwise addition of enzymes and simulated fluids during the gastric phase) and controlled gastric emptying. These capabilities are essential for replicating the intricate environment of the human stomach and intestines. The research team’s experimental results indicate that “the ‘digestion-chip’ successfully replicates the established static digestion INFOGEST protocol”. Moreover, “the semi-dynamic digestion kinetics observed with […]

INL hosted a two-day gathering focused on Functional Layered Materials

Between June 18 and 19, INL hosted a two-day action promoted by FUNLAYERS – a twinning initiative led by INL. The programme brought together stakeholders from academia, the private sector, and policymakers to engage with two actions. On the first day, participants delved into insightful talks and lively discussions on spin-based applications and energy storage. The exchange of ideas led to a fruitful discussion on the latest developments and future perspectives for Functional Layered Materials. The second day was dedicated to a hands-on session focused on writing a sound proposal under the MCSA Postdoctoral Fellowships. The workshop gathered young researchers, grant experts, and experienced scientists in a vibrant and insightful ideation exercise. These actions aimed to establish the foundations for facilitating knowledge sharing and cooperation between relevant actors in the field.