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Using graphene to purify water

According to the World Health Organization (WHO), in 2020, only 74% of the global population, equivalent to 5.8 billion people, had access to safely managed and accessed drinking water services. Efforts in water filtration and purification are critical for recovering clean water from wastewater effluents containing different classes of pollutants. Traditional water purification methods encompass a combination of processes, which are implemented at various stages of treatment. However, these methods are not effective in completely eliminating pollutants and contaminants from treated water. INL researchers propose the utilisation of layered graphene materials in membrane production to overcome these limitations, while providing high-level performance. Graphene is a single layer of carbon atoms arranged in a two-dimensional honeycomb lattice, possessing remarkable strength, conductivity, and other exceptional properties, making it a strong candidate for a diverse range of applications. These include potential applications in electronics for high-speed transistors, composite materials with enhanced strength and flexibility, and filtration systems due to its unique structure, robustness and flexibility. In a recently published paper in the Advanced Functional Materials journal, INL researchers from the 2DMD and the Water Quality research groups describe an efficient and environmentally-friendly approach to develop graphene-based filtration membranes with micrometre-size. The developed membranes […]

3DSecret project, coordinated by INL, targets metastasis patterns in breast cancer

Cancer remains the second most prevalent cause of mortality in developed countries, only behind cardiovascular disease. Critically, rather than the primary tumour, it is estimated that metastases are responsible for up to 9 in every 10 cancer deaths. The 3DSecret project, coordinated by INL, aims to unravel stochastic patterns that drive metastasis by combining a set of bleeding edge technologies: microfluidics, spectroscopy, nucleic acid sequencing, and artificial intelligence. The project, which unites partners from Portugal, Spain, Italy, and the UK, will use a multifactorial approach to study circulating tumour cells from the blood of breast cancer patients and identify patterns of cancer cell aggressiveness. The project kicked off in January, and a team of researchers from the Medical Devices research group at INL have successfully achieved the growth of cancer spheroids containing hundreds of breast cancer cells, originating from one single cell (figure below). The capacity of studying metastasis at the single-cell level avoids the averaging errors introduced by studying large cell populations and has the potential to allow the identification of cell-specific factors that can lead to the establishment of metastasis. The consortium has also designed a clinical protocol together with 2CA at Braga Hospital, which will allow utilising the […]

World Food Day 2023: INL is working towards a sustainable agri-food system

World Food Day is an annual event that highlights the importance of addressing global hunger and promoting sustainable agriculture. With the global population expected to reach 9.7 billion by 2050, the need for a robust and sustainable agri-food system has never been more critical. The INL Food Cluster is committed to foster innovation in agriculture and food production. INL researchers are at the forefront of this mission, striving to create a resilient, efficient, and sustainable agri-food system. Their multidisciplinary approach combines nanotechnology, biotechnology, and advanced materials to create solutions that enhance food quality, safety, and availability. This video showcases INL’s nanotechnologies to build a future food system that is sustainable and able to secure healthier, tastier, authentic, and safer foods, optimising and monitoring the processes all throughout the different parts of the whole food value chain.

Spintronics for neuromorphic computing: a breakthrough in energy-efficient information processing

In a recently published paper, the Spintronics research group describes a spintronic circuit as a basic programmable computing unit for neuromorphic computing. This circuit connects multiple spintronic devices with different functionalities in one circuit using a single fabrication process, which paves ways to fabricate complex neuromorphic computing systems. Neuromorphic computing offers a hopeful way to tackle some significant problems we face in technology, like the high energy consumption when processing a lot of data at once, which is similar to how our brains work. The idea behind neuromorphic computing is to handle information using many small processing units all at once. These units can be quite simple and can be set up in different ways. So, a good implementation needs to be energy-efficient, take up less space, and work quickly. It should also be able to grow and adapt for use in networks with millions of devices. INL researcher Tim Böhnert explains that “the computer memories should keep their memory over long periods and the processing units should activate above a certain threshold value. Thus, we are looking for other important properties such as non-volatility of the memories and non-linearity of the processing component.” In this paper, researchers investigated one […]

Revolutionising cancer monitoring: INL’s microfluidic chip enables earlier diagnosis and personalised treatment

Circulating tumour cells, or CTCs, are the agents responsible for cancer’s spread to distant parts of the body and have been an enigma in the realm of cancer research. Their analysis, termed liquid biopsy, allows for non-invasive and continuous monitoring of cancer through a simple blood test. However, until now, this analysis has been limited by the technologies available for CTC isolation which were primarily dependent on immuno-recognition and only captured a subgroup of CTCs (typically the less aggressive type). The Medical Devices research group at INL has pioneered a microfluidic system that holds the potential to transform the way we understand and fight cancer. This pioneering microfluidic chip marks a paradigm shift. The revolutionary system can efficiently and swiftly isolate all types of CTCs directly from whole blood samples, eliminating the need for complex pre-processing steps. The microfluidic chip also facilitates high-resolution imaging of the CTCs, enabling automation of the entire processing and analysis method, thus reducing user dependence, and has already been demonstrated in clinical testing to predict cancer progression up to 1 year earlier than existing technologies. The project CTC-OncoDynamics funded through the Caixa Impulse Consolidate program, and done in collaboration with INL’s spin-off company RUBYnanomed, aimed […]

INL researchers are working on a novel approach to fight a common disease in pigs

The project APTAcoli aims the development of a novel approach to fight a common disease that affects young pigs – enteric colibacillosis. This disease is caused by certain strains of Escherichia coli that attach to the small intestine and produce harmful toxins. These toxins lead to diarrhoea, dehydration, and acidosis. In the past, antibiotics were used to control the disease, but this practice is now banned in many countries. New strategies are needed to fight colibacillosis, and one promising approach is using aptamers, which are special molecules that can block the toxins and help the animals recover. Aptamers are like “molecular keys” that can selectively bind to specific targets. They have advantages over antibiotics, such as specific action and easy synthesis. However, they can be unstable in the body. To address this, synthetic nucleic acid mimics (NAMs), can be used to increase stability. INL researchers are working towards the development of new NAM-aptamers to block Escherichia coli toxins. To start, a selection process was performed to create NAM-aptamers specific to Escherichia coli toxins. Pablo Fuciños, who is leading this project in the Food Processing and Nutrition research group, adds “An encapsulation strategy is now being developed to protect the aptamers […]

DIAMOND-CONNECT: Advancing Brain Cell Activity Sensing with Quantum Diamond Technology

The DIAMOND-CONNECT project aims to use advanced quantum measurement methods for the observation of neuronal signalling. One promising technique involves using the glow of nitrogen-vacancy centres in diamonds to measure parameters such as temperature and magnetic fields on a tiny scale. The project plans to create a configuration where these nitrogen-vacancy centres are placed very close to neuronal cells at the surface of the diamond material to read their activity using quantum light signals. A special laser is used to place these centres in specific locations. INL researchers are optimising this colour centre creation for targeted sensing conditions within a network of brain cells. The diamond platform shall carry a tiny electrode that allows it to electrically stimulate the brain cells locally. The electrical activity of neurons creates a magnetic field that will be detected by light emitted from nitrogen-vacancy centres in the diamond. Jana Nieder, leader of the Ultrafast Bio- and Nanophotonics research group, explains that “using a powerful microscope for quantum measurements, we will be able to simultaneously observe the signals from all the centres in the diamond grid. This will help us to study the brain cell activity, neuronal communication and potential changes in response to neuronal stimulation or disease patterns.” The DIAMOND-CONNECT project aims to provide a […]

Investigating Air Quality in Schools with Advanced Sensors and Innovative Strategies

The LEARN project team is focused on understanding how air quality in schools affects children’s learning abilities. This unique EU-funded project aims to overcome existing technological barriers and develop new sensors to detect harmful air pollutants like volatile organic compounds and ultrafine particles. By measuring and studying indoor and outdoor air pollutants, as well as biomarkers of exposure, the researchers will assess their impact on children’s cognition. To achieve the project’s goals, a diverse team of leading researchers from various fields, such as environmental epidemiology, toxicology, air quality, systems biology, engineering, and social sciences, was assembled. To further explore these effects, INL researchers are using C. elegans as biosensors. Nivedita Chatterjee, who works in the Nanosafety research group, explains that “at INL, we set up a non-mammalian alternative model to study toxicity, development and behaviour, and we have been obtaining fascinating results. This will help us to better learn the effect of air pollutants on children’s health“. With LEARN‘s scientific achievements, we will have long-term impacts on indoor air quality technology, significantly improving the quality of life for children in Europe and leading to positive changes in society and the economy. Learn more about LEARN project and follow the project on social […]

Revolutionising optical systems: INL’s cutting-edge micro-mirror technology

Micro mirrors with large two-dimensional fields of view are a crucial breakthrough for achieving compact optical systems capable of reliable light manipulation, powering revolutionary applications like LIDAR and laser microscopy. INL researchers, in collaboration with the University of Minho and Bosch, have developed ground-breaking 1D and 2D micro-mirror technology using state-of-the-art MEMS (Micro Electronic Mechanical Systems) silicon-on-insulator (SOI)-based bulk micromachining. Impressively, neither complex bonding processes nor piezoelectric materials are needed to fabricate these mirrors, paving the way for more efficient and cost-effective solutions. The developed micro-mirrors feature purely electrostatic torsional out-of-plane actuation and capacitive sensing on both axes. “The unique self-aligned greyscale lithography micromachining process developed at INL, reduces gap tolerances and boosts performance by defining the vertical asymmetry of the comb electrodes with precision”, explains Inês Garcia, one of the leading researchers responsible for the success of the project. This technology has already made strides in LIDAR prototypes for automotive applications, but the potential does not end there. Diogo Aguiam adds “we are excited about the prospects of its implementation in compact laser microscopy and laser projection, opening up new horizons in scientific research and entertainment”.

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